Left Atrial Appendage Occlusion Device and Novel Oral Anticoagulants versus Warfarin for Stroke Prevention in Non-Valvular Atrial Fibrillation: A Systematic Review and Meta-Analysis of Randomized Control Trials Running title: Briceno et al.; Stroke Prevention Strategies in NVAF
نویسندگان
چکیده
Montefiore-Einstein Center for Heart and Vascular Care, Montefiore Medical Center, Albert Einstein College of Medicine, New York, NY; Texas Cardiac Arrhythmia Institute at St. David’s Medical Center; Department of Biomedical Engineering, University of Texas, Austin, TX; Division of Cardiology, Stanford University, Palo Alto, CA; Case Western Reserve University, Cleveland, OH; Scripps Clinic, San Diego, CA; Dell Medical School, Austin, TX; California Pacific Medical Center, San Francisco, CA; Department of Cardiology, University of Foggia, Foggia, Italy
منابع مشابه
Cost-effectiveness analysis of left atrial appendage occlusion compared with pharmacological strategies for stroke prevention in atrial fibrillation
BACKGROUND Transcatheter left atrial appendage occlusion (LAAO) is a promising therapy for stroke prophylaxis in non-valvular atrial fibrillation (NVAF) but its cost-effectiveness remains understudied. This study evaluated the cost-effectiveness of LAAO for stroke prophylaxis in NVAF. METHODS A Markov decision analytic model was used to compare the cost-effectiveness of LAAO with 7 pharmacolo...
متن کاملComparison of Approaches for Stroke Prophylaxis in Patients with Non-Valvular Atrial Fibrillation: Network Meta-Analyses of Randomized Controlled Trials
BACKGROUND Multiple novel oral anticoagulants and left atrial appendage closure devices (WATCHMAN) have been tested against dose-adjusted vitamin K antagonists in randomized controlled trials for stroke prophylaxis in non-valvular atrial fibrillation. No direct comparisons of these strategies are available from randomized controlled trials. We conducted the current analyses by combining efficac...
متن کاملLeft Atrial Appendage Closure as an Alternative to Warfarin for Stroke Prevention in Atrial Fibrillation: A Patient-Level Meta-Analysis.
BACKGROUND The risk-benefit ratio of left atrial appendage closure (LAAC) versus systemic therapy (warfarin) for prevention of stroke, systemic embolism, and cardiovascular death in nonvalvular atrial fibrillation (NVAF) requires continued evaluation. OBJECTIVES This study sought to assess composite data regarding left atrial appendage closure (LAAC) in 2 randomized trials compared to warfari...
متن کاملLeft atrial appendage occlusion devices versus pharmacological agents for stroke prevention in atrial fibrillation: testing the noninferiority margins.
We thank Drs. Messori and Trippoli for their comments on our paper (1). They importantly highlight the issue that the only 2 randomized trials in the field of left atrial appendage occlusion used warfarin as the control value. Both randomized trials, PROTECT AF (WATCHMAN Left Atrial Appendage System for Embolic PROTECTion in Patients With Atrial Fibrillation) (2) and PREVAIL (Watchman LAA Closu...
متن کاملPharmacological and Non-pharmacological Treatments for Stroke Prevention in Patients with Atrial Fibrillation
Atrial fibrillation (AF) is associated with significant risk of stroke and other thromboembolic events, which can be effectively prevented using oral anticoagulation (OAC) with either vitamin K antagonists (VKAs) or non-VKA oral anticoagulants (NOACs) dabigatran, rivaroxaban, apixaban, or edoxaban. Until recently, VKAs were the only available means for OAC treatment. NOACs had similar efficacy ...
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تاریخ انتشار 2015